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Do not take Imitrex with any of the following medicines:

  • amphetamine or cocaine
  • dihydroergotamine, ergotamine, ergoloid mesylates, methysergide, or ergot-type medication - do not take within 24 hours of taking sumatriptan
  • feverfew
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate - do not take sumatriptan within 2 weeks of stopping MAOI therapy
  • other migraine medicines like almotriptan, eletriptan, naratriptan, rizatriptan, zolmitriptan - do not take within 24 hours of taking sumatriptan
  • tryptophan

Imitrex may also interact with the following medications:

  • lithium
  • medicines for mental depression, anxiety or mood problems
  • medicines for weight loss such as dexfenfluramine, dextroamphetamine, fenfluramine, or sibutramine
  • St. John's wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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